Moch Izzul Haq Al Maruf, Wahyu Widiawati, Al Viyah Rahmaidah, Mona Sari, Yusril Yusuf
Background: The utilization of bioceramics for medical implants necessitates the incorporation of antibacterial properties to mitigate post-surgical inflammation of bone tissue. Objective: In this research, Zn2+ions were introduced as an antibacterial agent into carbonate-hydroxyapatite-based honeycomb Scaffold bioceramics (CHA/HCB), with varying doping concentrations, to investigate the impact of Zn2+on the antibacterial activity of CHA/HCB against Staphylococcus aureus and Pseudomonas aeruginosa. Methods: CHA was synthesized from abalone shells through the co-precipitation method, followed by the fabrication of a CHA-based scaffold with HCB using the porogen leaching technique. Subsequently, the Zn ion doping process was executed through the ion exchange method, using concentrations of 0.05 M, 0.1 M, 0.15 M, and 0.2 M. The samples were characterized using XRF and antibacterial test. Results: The XRF results revealed that the Ca/P ratio of CHA/HCB was within the range of 1.48-1.85, indicating a declining trend with the introduction of Zn2+as a dopant. Nevertheless, these results remained within acceptable ranges, ensuring compatibility with bone tissue. In terms of antibacterial activity, the measured inhibition zone diameters increased alongside the increase of Zn concentration. The zone diameters ranged from 14.3 to 22.0 mm against Staphylococcus aureus and 13.7 to 21.4 mm against Pseudomonas aeruginosa. Conclusion: The findings suggest that Zn doping in CHA/HCB bioceramics has a potential an antibacterial agent in CHA scaffolds as well as potential for practical applications, particularly in reducing the risk of postoperative infection in bone tissue implantation. © The Author(s) 2025
Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta, Indonesia; Erasmus Mundus Master in Biomedical Engineering (EMMBIOME), University of Kragujevac (Serbia), University of Patras (Greece), University of Medicine and Pharmacy Grigore T. Popa, Romania; Department of Physics Education, Faculty of Mathematics and Natural Sciences, Universitas Negeri Yogyakarta, Yogyakarta, Indonesia; Research Collaboration Center for Biomedical Scaffolds National Research and Innovation Agency of the Republic Indonesia (BRIN), Universitas Gadjah Mada, Yogyakarta, Indonesia
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