Jeffry Julianus, Handika Immanuel, Yoga Priastomo, Susalit Setya Wibowo, Eti Nurwening Sholikhah, Jumina Jumina, Hana Anisa Fatimi, Yehezkiel Steven Kurniawan
The C-4-hydroxy-phenylcalix[4]pyrogallolarene is a compound proven to inhibit tyrosinase enzyme activity. This activity makes C-4-hydroxy-phenylcalix[4]pyrogallolarene as a potential skinbrightening agent. However, the poor water solubility of this compound limits its application as a skin brightener. Therefore, this study formulated C-4-hydroxy-phenylcalix[4]pyrogallolarene liposomes to address this issue. The liposomes were prepared using the thin-layer lipid film hydration method with L-αphosphatidylcholine as the lipid base. The resulting C-4-hydroxyphenylcalix[4]pyrogallolarene liposomes were found in spherical forms, and they exhibited multilamellar vesicle characteristics. This study also examined the influence of hydration temperature and L-α-phosphatidylcholine concentration on liposome size and polydispersity index (PDI). ANOVA analysis using Design Expert-13 indicated that the factors of hydration temperature, L-αphosphatidylcholine weight, and their interaction all influenced the size and PDI of the resulting C-4-hydroxy-phenylcalix[4] pyrogallolarene liposomes. © 2025, ZITA Medical Management. All rights reserved.
Faculty of Pharmacy, Universitas Sanata Dharma, Sleman, Yogyakarta, Depok, 55281, Indonesia; Department of Chemistry Education, Faculty of Mathematics and Natural Science, Universitas Negeri Yogyakarta, Jalan Colombo No 1, Yogyakarta, 55281, Indonesia; Research Center for Process and Manufacturing Industry Technology, National Research and Innovation Agency (BRIN), KST BJ Habibie, Banten, 15314, Indonesia; Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, 55281, Indonesia; Pharmacy Study Program, Faculty of Mathematics and Natural Science, Universitas Sebelas Maret, Surakarta, 57126, Indonesia
