Nurfina Aznam, Sri Atun
The purpose of this research was to observe the effects of temulawak (C. xanthorhiza) powdered and instant herbal products on hypercholesterol by in vivo. This research began with the manufacture of temulawak powdered and instant medicinal products from standard raw materials. The activity assay by in vivo using female Wistar strain rats aged 50 days with a weight around 150 grams which was fed with pellets and quail egg yolk. There were five rats in each group and were placed in a cage with a temperature of 25-32º C, and 98% relational humidity. The treatment to the tested animals was done to observe the rat blood lipid profile due to the treatment with temulawak powdered and instant herbal products, compared to the negative control (without quail egg yolk) and the positive control which was given the quail egg yolk and simvastatin as an antihypercholesterol. The treatment of each group of rats lasted for 50 days. All the rats were taken the blood from sinus orbitalis for the lipid profile analysis which includes determining total cholesterol levels, triglycerides, HDL (high density lipid), and LDL (low density lipid), before and after giving the Quail egg yolk, after a two week and a four week administration of temulawak powdered and instant herbal products. The results show that there are effects of the dose and four week duration of administration of temulawak powdered and instant herbal products on the levels of cholesterol, triglycerides, HDL, and LDL in the rats’ blood. © 2016, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved.
Department Chemistry education, Faculty Mathematics and Natural Science, Yogyakarta State University, Jl. Colombo No. 1, Depok, Sleman, Yogyakarta, 55281, Indonesia
