Kun Sri Budiasih, Chairil Anwar, Sri Juari Santosa, Hilda Ismail, Ika Puspita Sari
Investigation of an in vivo application of chromium-amino acid complexes was conducted on nicotinamidestreptozotocin induced diabetic Wistar rats. The rats were divided into 9 groups each consist of 4 animals. Three groups are control (+) with chromium picolinate (CrPic), control (-)diabetic group (DM) and control non diabetic (non DM). Furthermore, three groups wereexamined on the effect of Formula A (Cr-glutamate by 1:3 ratio)at dose (100, 200 and 400 μg/day). In addition, the last 3 groups were studied on the effect of different formula of Cr (III)- glutamato made of Cr-glutamate by ratio 1:2 (200 μg/day), Cr-glycine (1:3) and Cr-cysteine(1:3) complexes. The blood glucose levels were measured before and after treatment. All formulas gave significant effect in lowering glucose level (p 0.05) compared to diabetic rats control group.
Chemistry Education Dept, Yogyakarta State University, Indonesia; Chemistry Dept, Universitas Gadjah Mada, Yogyakarta, Indonesia; Universitas Gadjah Mada, Yogyakarta, Indonesia
