Indyah S. Arty, Henk Timmerman, Mochammed Samhoedi, Sastrohamidjojo, Sugiyanto, Henk Van Der Goot
A series of benzylideneacetophenone derivatives have been synthesized and found to show potent inhibition of the lipid peroxidation (LPO) in rat liver microsomes. All 19 compounds prepared in this series are LPO inhibitors. The highest activity was found in para hydroxy derivatives with two meta tert-butyl substituents. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
FPMIPA IKIP Yogyakarta, Karangmalang, Yogyakarta, Indonesia; Leiden/Amsterdam Ctr. for Drug Res., Div. Med. Chem., Dept. P., Amsterdam, Netherlands; Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia; FMIPA, Gadjah Mada University, Yogyakarta, Indonesia
