S. Atun, Y. Dewi, N. Aznam
Curcuminoid is the main compound found in the Curcuma xantorrhiza rhizome. C. xantorrhiza plant which in Indonesia is known as temulawak is an herbal plant that is traditionally used to cure hepatitis, increase stamina, and as an anti-cholesterol. To enhance the stability, solubility and activity of the curcuminoid, should be developed into a product nanoparticle. The purpose of this study was to characterize nanocurcuminoids from ethanol extracts from the C. xantorrhiza rhizome loaded by chitosan and alginic acid, and its antioxidant activity test. The nanocurcuminoid formulation method uses ionic gelation. Chitosan nanocurcuminoid is made by mixing curcuminoid solution and chitosan solution, then adding sodium tripolyphosphate (Na-TPP). Meanwhile, alginic nanocurcuminoids are made by mixing a solution of curcuminoids and alginic acid solutions, which are then added to calcium ions. The activity of the nanocurcuminoid products obtained was tested as an antioxidant activity by the DPPH method (2,2-diphenyl-1-picrylhydrazyl). The results showed that chitosan nanocurcuminoid can be obtained in the addition of chitosan and sodium tripolyphosphate having a particle size of 251.8 to 874.3 nm, polydispersion index (PI) 0.104 to 0.376, with a zeta potential of +19.4 to +30.8 mV. Alginic nanocurcuminoid can be formulated in the addition of alginic acid and calcium chloride having a particle size range of 161.6 to 210 nm, PI 0.115 to 0.444, with a zeta potential of-12.8 to-27.8 mV. The morphology of nanocurcuminoid particle products was a spherical surface. Chitosan nanocurcuminoid and alginic nanocurcuminoid showed higher antioxidant activity than original curcuminoid. © RASĀYAN. All rights reserved.
Department Chemistry Education, Faculty of Mathematics and Natural Science, Universitas Negeri Yogyakarta, Jl. Colombo No.1 Depok, Sleman, Yogyakarta, 55281, Indonesia
