Kartika Ratna Pertiwi, Sri Atun
To date, only few studies summarize which herbal plants mostly studied in immunity. This study aims to search for the most Indonesian herbs studied as immunomodulator, and to identify their potencies. The findings hope-fully could lead to a new formula of herbal immunosupplement. This systematic review was designed with hermeneutic approach, following PRIS-MA guideline. Literature searching was performed in Google Scholar and Indonesian Scholar Database, using Boolean operator and citation track-ing. Relevant articles were identified to list the most Indonesian herbs studied as immunomodulator. Quality assessment was conducted with Newcastle-Ottawa Scale and the extracted data were analyzed descrip-tively. Record identification hit 574 articles, of which were screened, re-sulting to 241 studies. Data extraction was taken from 17 studies. Among the most herbal studied, Phyllanthus niruri, Andrographis paniculate and Nigella sativa reveal to be the potential herbal plants to develop a new herbal mix immunosupplement, due to their proinflammatory and phago-cytic-activator properties. © 2021 Kartika Ratna Pertiwi, et al.
Department of Biology Education, Universitas Negeri Yogyakarta, Indonesia; Department of Chemistry Education, Universitas Negeri Yogyakarta, Indonesia
