Emi Norzehan Mohamad Mahbob, Mohamad Syahrizal Ahmad, Illyas Md Isa, Norhayati Hashim, Anwar Ul-Hamid, Mohamad Idris Saidin, Suyanta M. Si
This work explicates a simple, rapid, and sensitive method for the electrochemical detection of dopamine (DOP) utilising 1-phenyl-3-methyl-4-orthofluorobenzoyl-5-pyrazolone (HPMoFBP)/multiwalled carbon nanotube (MWCNT) carbon paste electrode (CPE). The electrochemical behaviour of DOP was performed through cyclic voltammetry and square wave voltammetry. HPMoFBP/MWCNT showed a higher current at the lower potential for the oxidation of DOP compared to bare MWCNT. The sensor's improved electrocatalytic activity was observed to detect in a 1.0 x 10-1 M phosphate buffer saline (PBS) solution at pH 8.0. A good linear regression analysis was observed between electrical response and the concentration of DOP in the range of 1 to 1000 µM. Under optimized experimental conditions, 1.0 x 10-7 M has been determined as the limit of detection (LOD). The sensor has expressed considerable sensitivity towards DOP detection without interference and is successfully used to determine DOP in dopamine hydrochloride injection. © 2023 Chemical Society of Ethiopia and The Authors.
Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Perak Darul Ridzuan, Tanjong Malim, 35900, Malaysia; Faculty of Applied Sciences, Universiti Teknologi MARA, Perak Branch, Tapah Campus, Tapah Road, Perak Darul Ridzuan, 35400, Malaysia; Nanotechnology Research Centre, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Perak Darul Ridzuan, Tanjong Malim, 35900, Malaysia; Center for Engineering Research, Research Institute, King Fahd University of Petroleum & Minerals, Dhahran, 31261, Saudi Arabia; Department of Chemistry Education, Faculty of Mathematics and Natural Science, Yogyakarta State University, Indonesia
