Ngadikun, Usi Sukorini, Kuncoro Asih Nugroho, Metamalik Pasala
One of the main causes of mortality due to cancer is breast cancer (BC). The high incidence and mortality rates are partly due to the absence of the early detection of this cancer. Moreover, the investigation of biomarkers which play a key role in the prognosis of the disease is critical. The present study aimed to develop a simple early method for detecting BC with three parameters, namely the erythrocyte sedimentation rate order (ESRO), neutrophil‑lymphocyte ratio (NLR) and platelet‑lymphocyte ratio (PLR) that indicate the presence of biomarkers in patients with BC. These parameters were evaluated in 27 patients with BC using receiver‑operating characteristic (ROC) curve analysis and were then compared to the normal group (n=29). The present study calculated ROC, the area under the curve (AUC), sensitivity, and specificity values to determine the ESRO, NLR and PLR levels that can most efficiently differentiate between patients with BC and control subjects. The ESRO parameter exhibited a better performance than NLR and PLR in differentiating patients with breast cancer and normal subjects from whole blood samples (AUC values were 82, 65 and 73%, respectively), for the selected cut off points of 6.075, 2.86 and 216.0, respectively. Thus, it can be concluded that ESRO performs better as inflammatory parameter to reflect the presence of BC compared to NLR and PLR. Copyright © 2025 Ngadikun et al. This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.
Department of Biochemistry, Faculty of Medicine, Public Health and Nursing Gadjah Mada University, Yogyakarta, 55281, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Public Health and Nursing Gadjah Mada University, Yogyakarta, 55281, Indonesia; Department of Physics Education, Yogyakarta State University, Yogyakarta, 55281, Indonesia; Faculty of Pharmacy, Gajah Mada University, Yogyakarta, 55281, Indonesia
